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Research indicates that the introduction of epoxy groups primarily inhibits apoptosis by stabilizing mitochondrial function, while functional groups such as carboxyl, carbonyl, or hydroxyl groups act as secondary pharmacophores, significantly enhancing free radical scavenging efficiency through electron delocalization effects ( The protective effect of rhodioloside, the primary component of Rhodiola crenulata (Hook

10.1016/j.arabjc.2022.103798 56 SicilianoG.MonteduroA

Quercetin can promote the clearance of senescent cells, which likely contribute to multiple pathways in age-related disorders across multiple systems (141)

Sondergard S, Cintin I, Kuhlman A et al

Ringing in the ears (tinnitus) can also signal high ibuprofen levels