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Trimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carniti...

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To counteract these adverse effects, AAV-mediated SIRT1 overexpression (AAV-SIRT1) has been explored as a therapeutic strategy to restore SIRT1 levels and protect against NIHL.