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Bypasses Regulation: Its design limits its affinity for IGF-binding proteins (IGFBPs), which normally restrict IGF-1's activity

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)

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In double-blind, placebo-controlled trials, daily application of GHK-Cu cream at 3% concentration for 12 weeks produced a 70% increase in skin collagen thickness as measured by ultrasound imaging, a 40% increase in skin elasticity, and visible reduction in fine lines and wrinkles