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Moreover, the necessary treatment of pain can lead to complexities created by dependence or hyperalgesia [49]

To take advantage of these positive benefits, pharmaceutical drugs have been developed that either limit endogenous GLP-1 degradation by inhibiting dipeptidyl peptidase-4 (DPP-4 inhibitors such as sitagliptin, saxagliptin, linagliptin, and alogliptin) or activate GLP-1 receptors (GLP-1R agonists such as dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide)