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IFN- activates STAT1 phosphorylation and downregulates solute carrier family 3 member 2 (SLC3A2), glutathione, and GPX4, thereby triggering ferroptosis in SGEC

Oxygen remains critical for brain glucose metabolism in the glycolytic pathway, and it has been demonstrated that reperfusion with hyperoxia (pressure of arterial oxygen 300 mmHg) after CA is associated with poor functional outcomes (Richards et al

In addition to enhancing glucose uptake, KRAS mutations upregulate key enzymes in the glycolytic pathway that drives the conversion of glucose into pyruvate and ultimately lactate, such as HK, phosphofructokinase-1 (PFK1), and lactate dehydrogenase A (LDHA) (Fig

Troubleshooting dosing issues Despite careful planning, you may encounter issues during the dosing process