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GH-deficient subjects required a dose of approximately 60 ?g/kg/d, whereas those with idiopathic short stature required more than 120 ?g/kg/d, which exceeds the labeled dose and would not be reasonable to use in a standard clinical care of a pediatric patient

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Male MC4R KO and C57BL/6 J mice (Jackson Laboratory Japan, Kanagawa, Japan) were fed normal chow (CE-2
