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Theriogenology 160, 6171
In hypoxic conditions, elevated EPO expression promotes erythropoiesis, enhancing oxygen transport and thus adaptation to the hypoxic environment (36)
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Three studies contained data for more than one brain region: the results for these different brain regions were included in the final meta-analysis, giving a total of 11 studies in the final list of brain regions with data available

Other orthobiologics such as stem cell therapy or PRP, even newly developed cell editing drugs like Invossa for knee osteoarthritis have robust safety data in humans and ongoing randomized controlled trials to determine their efficacy