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Relation of serum ascorbic acid to mortality among US adults
Emerging translational strategies These include SGLT2 inhibitors, PARP inhibitors, necroptosis blockers [216], ferroptosis inhibitors [153], and NLRP3-targeting compounds [59, 60, 145], which have demonstrated significant efficacy in experimental models and, in selected settings, preliminary benefits in clinical studies [153, 216]

These effects are often transient and manageable

J.FerrisC

The sense strand is released and degraded, as AGO2 and the antisense strand are transported into the cell nucleus, where they bind to the promoter region (Fig