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Drug Resist Updates 9:227246 Attwa EM, Elkot RA, Abdelshafey AS, Hafez AR (2019) Subcutaneous methotrexate versus oral form for the treatment and prophylaxis of chronic plaque psoriasis

In Phase I/II combination study with irinotecan and cetuximab in selected patients with KRAS WT locally advanced or mCRC (NCT01075048), the addition of tivantinib did not improve PFS, the primary endpoint (Eng et al., 2016)

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The moderately acidic environment can trigger Fe 4 Se 2 W 18 NCs to release Fe 3+ , which can be reduced by GSH to produce Fe 2+ along with the decomposition of H 2 O 2 for OH production, rendering cancer cells more susceptible to oxidative stress (Zhou et al., 2021)