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doi: 10.1016/B978-0-323-95590-4.00009-6 90 PalmaARuiz-MontoyaMDazMJGirldezIMoralesE

Approved pharmacological treatments, such as acetylcholinesterase inhibitors and the N -methyl-d-aspartate (NMDA) receptor antagonist memantine, provide only modest symptomatic relief and do not alter disease progression

Follicular fluid-derived exosomal LncRNA LIPE-AS1 modulates steroid metabolism and survival of granulosa cells leading to oocyte maturation arrest in polycystic ovary syndrome

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In the Phase 2 obesity data the weight curve was still trending downward at 48 weeks, so a genuine plateau at a tolerated maintenance dose may simply reflect the body settling toward a new set point rather than the protocol failing