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Studies have shown that in humans, intravenous injections of arginine (30 g per 30 min) can cause a 72-fold increase in the plasma levels of arginine (100 mol/L to 7200 mol/L), accompanied by a 15% decrease in blood pressure (28)
Direct inhibition of HDAC4s transcription leading to reduced overall HDAC activity, has been revealed by treatment of the medulloblastoma cells with curcumin (Lee et al., 2011)
10.1093/jmcb/mjs049 J
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