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TMAO-mediated neurodegeneration involves activation of peripheral/central inflammatory pathways (NF-B, NOD-, LRR-, NLRP3 inflammasomes, MAPK/JNK) (145)

These findings emphasize the need for caution regarding carnitine supplementation, particularly in individuals with preexisting metabolic or cardiovascular vulnerabilities [55]

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Elongation involves condensation of fatty acyl-CoA groups with either acetyl-CoA or malonyl-CoA