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Cancer inhibition mechanisms associated with the effect of melatonin have been described in various types of neoplasms both in vitro and in vivo, including breast, endometrial, prostate, ovarian, laryngeal, liver, kidney, lung, gastric, pancreatic, and colorectal, among others [30]

The intranasal (nose-to-brain) administration method offers a number of advantages, as it avoids first pass effect, is less intrusive, provides a broad surface area for absorption, and reduces nontargeted delivery to minimize systemic exposure [7, 25]

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Gently pat into skin to increase absorption.