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Before the origin of genes and proteins, simple molecular systems such as monomeric Cys-FeS clusters could have driven protometabolism

This fact points outs the critical role of mitochondrial oxidative metabolism in cancer ( in vitro , in vivo , and epidemiological studies showed a very heterogenous contribution of glycolysis and Oxphos to cancer metabolism

In addition to human health, aflatoxins also pose significant risks to livestock and poultry

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Most notably, the ESCRT-III subunit charged multivesicular body protein 2B (CHMP2B) is mutated in amyotrophic lateral sclerosis and frontotemporal degeneration 11,30,31 , whereas mutations in the ESCRT-I subunit ubiquitin associated protein 1 (UBAP1) underlie hereditary spastic paraplegia (HSP) 32