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3.11 Histopathology of hippocampus of rat brain The examination of a section of the cerebral cortex stained with hematoxylin and eosin (H&E) reveals several critical observations: (A) Cortical neurons () characterized by rounded vesicular nuclei (yellow ) display sharply demarcated nuclear contours, while blood vessels (v) are accompanied by a narrow perivascular space indicative of degenerated and shrunken neurons

331.T A Howlett, S Tomlin, L Ngahfoong, L H Rees, B A Bullen, G S Skrinar, J W McArthur

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3 months) restored AngIV decline in APP/PS1 mice, saved the cognitive function of mice, improved neuronal loss in mice and reduced neuroinflammation and inhibited glial activation in the mouse brain [6]