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foxo4 dri senolytic mice baar 2017 FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation FOXO4-DRI
Description
This is the phase where the synergistic effects become most apparent

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Many more studies done on animals and humans would need to be done in order to substantiate this claim

Neurotrauma 26 , 827840 (2009)

Mutations in the Casitas B-cell lymphoma (Cbl)-binding domain are demonstrated to be oncogenic because binding of Cbl to Y1003 causes Met ubiquitination that is vital to maintenance of physiological Met activation and prevention of continued activation of Met (Peschard and Park, 2007)
