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PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats

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Importantly, when combined with curcumin, 3,4-DHPV exhibited a strong synergistic anti-inflammatory effect at low micromolar concentrations (5 M 3,4-DHPV + 5 M curcumin), markedly reducing the expression of multiple pro-inflammatory genes (e.g., IL-6, MCP-1, COX-2, IL-1, TNF-, iNOS) and their secreted protein levels (Marcolin et al., 2025)

Sixteen patients had plantar fasciitis in both feet, while nine had it in one foot