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The subject headings and text keywords included those related to the population of interest (i.e., IC, BPS), intervention (relevant treatments such as medication, instillation, intravesical injection, physical therapy and/or others), comparison (placebo or control), and outcomes of treatments: 1) individual symptoms (pain, frequency, urgency and nocturia), 2) structured questionnaires (interstitial cystitis problem index [ICPI], interstitial cystitis symptom index [ICSI], pelvic pain urgency frequency symptom scale [PUF] and functional bladder volume [FBV])

Key findings: Used daily Used continuously Used for months , not weeks Demonstrated safety without tolerance development No cycling protocols were included

Despite all the pressures of recovery, take some time not only for needed serious conversations, but also for some lighthearted fun

others have settled on 1 mg/day for 20-day cycles repeated 3-4 times per year as a middle-ground approach