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Acknowledgements This work was supported by grants from the Council of Scientific and Industrial Research, New Delhi (09(370)/92/EMR-II) and the Department of Science and Technology (Govt of India), New Delhi (SP/SO/B40/97)

Iron release from ferritin induced by light and ionizing radiation

Compared to curcumin itself, the biological effectiveness of curcumin metabolites, excluding 4HC, is considerably reduced (82, 116)

pyruvate dehydrogenase is dephosphorylated, and the pyruvate dehydrogenase complex is activated

The neurological symptoms would then result from reduced methylation of neuronal lipids and neuronal proteins, such as myelin basic protein, which makes up approximately one-third of the myelin of peripheral nerves and the spinal cord [36,37,38]