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The authors would like to apologize to many of our research colleagues whose work could not be cited (in both parts of this review, I and II) due to limitations in mansucript length

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

However, over time, this theory has been increasingly revised as new findings emerged and newer models were proposed

Vitamin B6 injection (pyridoxine) is essential for protein metabolism, energy production, and normal nervous system function