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Conversely, agents with neuroprotective properties used in traditional medicine for conditions like forgetfulness and tinnitus, such as Hawthorn Leaf Flavonoids, show efficacy in AD models by reducing oxidative stress and neuroinflammation via the Nrf-2 pathway, indicating common protective mechanisms (Xu et al., 2023)

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Kondratov RV, Kondratova AA, Gorbacheva VY, Vykhovanets OV, Antoch MP (2006) Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock

[DOI] [PMC free article] [PubMed] [Google Scholar] 156.Liu X.X., Wu P.F., Liu Y.Z., Jiang Y.L., Wan M.D., Xiao X.W., Yang Q.J., Jiao B., Liao X.X., Wang J.L., et al