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Partially purified fiber cell membranes have substantially lower cholesterol/phospholipid ratio than was found in the whole tissue, although membranes from nuclear fibers still have proportionally higher cholesterol content than membranes from the cortex

doi:10.4049/jimmunol.176.1.567 110

However, the magnitude and durability of these effects remain to be clarified in larger, well-designed randomized trials Rheumatic diseases are characterized by chronic inflammation, immune dysregulation, and oxidative stress, processes that collectively contribute to joint damage, tissue degeneration, and bone loss

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Apoptosis is initiated by apoptotic signals, followed by the interaction of apoptosis regulatory molecules to activate protein hydrolases (caspases), leading to a continuous cascade of reactions