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Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology

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Availability of data and materials The data that support the findings of this study are available from KGK Synergize Inc

10.1001/jamanetworkopen.2020.37341 105 WangM.PuD.ZhaoY.ChenJ.ZhuS.LuA.et al (2020a)