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Mitochondrial dysfunction is associated with increased oxidative stress and inflammation

Conclusion FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

It also helps prevent the formation of new fat and may improve bone density

Short-term GH therapy for 3 months increases the activity of succinate dehydrogenase, which represents the mitochondrial function in human quadriceps muscle (Gonzalez et al., 2018)

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