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Zinc v enzym detoxification Zinc l yu t cu thnh ca nhiu enzym chuyn ho, bao gm cc enzym cytochrome P450, nhng enzyme quan trng trong vic chuyn i cc cht c thnh dng t c hn

[11] A case-control study conducted in China showed that patients with two copies of the NQO1 C609T (NQO1*2 polymorphism) mutation had a 7.6-fold increased risk of benzene poisoning compared to those who carried one or two wild-type NQO1 alleles

Most childhood-onset GHD is termed idiopathic, meaning there is no known cause

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

COM 2011