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Longevity varies by product and treatment area, but most dermal fillers last between 6 and 18 months before a touch-up is needed

HSS Journal , 21, 485 495

Chang H, Park JH, Min KH, Lee RS, Kim EK

Cytotoxicity assays of RH-PLGA/chitosan nanoparticles using peripheral blood mononuclear cells and Raw 264.7 macrophages showed IC50 values of 1414 g/mL and 19.3 g/mL, respectively
