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In ischemic stroke, blood vessel blockage results in glucose and oxygen deficiency, which triggers several biological response pathways and ultimately leads to irreversible brain damage (Sharma et al., 2022)

Deletion of SARM1 gene is neuroprotective in two models of peripheral neuropathy

Thus, it takes part in the anti-inflammatory response as well as antioxidant and immune reactions, and can also indirectly regulate the ability of cells to apoptosis [158]

Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs

And the development of new targeted drugs using siRNA interference technology has attracted significant attention