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Although both forms of testing are valuable, the scientific nature of in-vitro testing in a lab environment removes human bias and provides objective results on efficacy

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Furthermore, RSL3 treatment markedly increased the amount of oxidized PE and ether-linked PE (ePE) species

In most cases, such diagnoses can be ruled out through clinical history and physical examination.1,2,4 With only a few reports, lingual melanotic macule is considered a rare or underdiagnosed entity.1,2 In a review of the literature in 2015, Savoia et al