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In contrast, in models with GLS mutations, glutamate metabolism in tumor cells is restricted, which increases Gln concentration in the microenvironment and T-cell uptake and antitumor activity

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Uma das explicaes para isso seria a de que um organismo saudvel j possui estoques suficientes de L-carnitina nos msculos e, diante de doses extras, o corpo faz uma autorregulao, reduzindo a produo de L-carnitina e priorizando a sntese de outras substncias