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Spisso et al

This stoichiometric conversion serves as a quantifiable biomarker for autophagosome biogenesis monitoring, establishing LC3 lipidation as the gold-standard metric in autophagy assessment

Taken together, these findings suggest that upon DNA damage, substrate selectivity may be regulated by PTMs that alter binding ability of SIRT1 to specific substrates, rather than the enzymatic activity of SIRT1, which makes possible substrate selectivity in which the p53 deacetylation is suppressed while the MDM2 deacetylation is maintained

Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ , Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS