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Synthetic neoantigens formed by proteasome-resistant modification of KRAS G12C peptides with covalent inhibitors are loaded onto HLAs as so-called haptenated peptides or p* (peptides still carrying the covalent inhibitor) and presented as p*MHCs on the cancer cell surface as homogeneously modified epitopes

[DOI] [PMC free article] [PubMed] [Google Scholar] 200.Karampitsakos T., Papaioannou O., Sampsonas F., Tzouvelekis A

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Among the most discussed topics in advanced research circles is the "mots c retatrutide stack," a theoretical combination that aims to leverage distinct mechanisms for potentially enhanced metabolic regulation

Imatinib, Dasatinib, Sorafenib, Sunitinib, and Cabozantinib are examples of multi-target TKIs that have been evaluated for GBM [38,146,150,151], even though, until now, no TKI has been approved for GBM, mostly due to lack of success in clinical trials