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Second, elevated antioxidant metabolites such as arginine and citrulline paralleled skin lightening effects, consistent with oxidative stress mechanisms in melasma [27]

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This is the single biggest mismatch between expectation and evidence, and it's worth revisiting even after reading the section above

Chinta SJ, Kumar MJ, Hsu M, Rajagopalan S, Kaur D, Rane A, Nicholls DG, Choi J, Andersen JK (2007) Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration

The tumor-specific isoform ct-OATP1B3-V1 enhances chemotherapy sensitivity by localizing to the plasma membrane and importing drugs