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GHK-Cu activating tumor suppressors while downregulating metastasis genes is the opposite of what most people assume
doi: 10.1016/j.yhbeh.2017.09.013
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In vivo and in vitro experiments clarify the hierarchical regulatory mechanisms: Butyrate directly regulates Th17/Treg homeostasis, promotes Treg differentiation through the HDAC1/FoxP3 pathway, and simultaneously inhibits Th17 activation and the expression of IL-17, IL-23, and RORt (89, 90)
doi: 10.1105/tpc.108.060335
