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This effect is independent of other known risk factors, suggesting a direct influence of the S453I variant on hepatic lipid metabolism
Wang JY, Wu YH, Liu SJ, et al

Restoring normal neurological function, or at least slowing disease progression, should be the focus of new therapies to address DN
References Blount, Z

Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells