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Description
In vitro studies on cardiomyocytes showed that Sac/Val reduced doxorubicin-induced mitochondrial reactive oxygen species generation and improved cell viability [168]
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10.1021/bm049284w 72 RaoZ.LinZ.SongP.QuanD.BaiY

This model proposes that the initial interaction between enzyme and substrate is relatively weak, but that these weak interactions rapidly induce conformational changes in the enzyme that strengthen binding and bring catalytic sites close to substrate bonds to be altered

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