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451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

As a result, renal function is compromised following DOX administrationin turn, serum urea and creatinine concentrations increase while serum albumin, urea, and creatinine clearance decrease, ultimately leading to extreme proteinuria [33, 34]