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Notably, iron-overloaded microglia can amplify neurodegeneration by releasing oxidative metabolites and inflammatory mediators upon ferroptotic stress (see also Section 7.5), thereby harming nearby neurons
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Research has found that in a model of metabolic dysfunction-associated steatotic liver disease (MASLD), the level of the key microbial bile acid metabolite 7-keto-deoxycholic acid (7-KDCA)a confirmed FXR antagonistis elevated
Structure and function of the spleen
The observed benefits can be attributed to the combination of auditory sensory input along with movement training
