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Lung Cancer In 2017, a study found that men taking B12 supplements appeared to have an increase in lung cancer risk

Infections : Tick-borne infections like Lyme disease , viral infections like Epstein-Barr, and gut infections like candida may lead to Hashimotos disease and an underactive thyroid

doi: 10.1001/jama.2021.12531

Some patients may require injections more frequently, and if a true deficiency is identified, several injections over 1-2 weeks are needed, known as a loading dose

Theories include alteration of bile acid metabolism, small intestinal bacterial overgrowth, effects on intestinal motility and interference by metformin on vitamin B12-intrinsic factor absorption in the terminal ileum