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1 These include the direct effect of alcohol on an individual, including alcohol withdrawal and metabolism rates, as well as non-alcohol causes, including other components found in the consumed beverages, use of other drugs (especially nicotine), personality type and family history of alcoholism

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As GR depends on the availability of NADPH, we propose that after prolonged conditions of higher temperature and humidity, progressive metabolic changes may be related to the depletion of this nucleotide