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Ann Rheum Dis (2020) 79(11):150614

Because ob/ob mice administered LNP-anti-miR-30e-5p or LNP-Control did not significantly differ in lipid profile or body weight (Supplemental Figure 5D, 5E), the mechanism by which LNP-anti-miR-30e-5p reduced atherosclerosis would be independent of hyperlipidemia (Figure 7L-M)

Warning Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle

This blockade leads to increased synaptic concentrations of these monoamines, which in turn enhances the activity of descending inhibitory pathways originating from the brainstem, particularly the RVM
