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Furthermore, the degradation of GSH and the suppression of immune responses requires phosphorylation of RipAY (Wei et al., 2017)

[DOI] [PMC free article] [PubMed] [Google Scholar] Zhang P., Xu Y.P., Sun J.X., Li X.Y., Wang L.H., Jin L.J

Abstract Background: Cadmium (Cd) is a hazardous ecological contaminant implicated in substantial oxidative stress (OS), nitrative stress, inflammation, apoptosis and fibrosis, particularly in the heart and liver

Taken together, these studies confirm the role of the MGST2-LTC 4 pathway in mediating ER stress-triggered kidney damage, apoptosis, oxidative DNA damage and ER stress-triggered morbidity in vivo