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Description
They represent what rigorous clinical development looks like: Phase I through Phase III trials, post-marketing surveillance, and manufacturer accountability

Baseline liver function tests including AST, ALT, and bilirubin establish pre-treatment values
R.SpeddingM.KenakinT.ChristopoulosA.International Union of Pharmacology Committee on Receptor Nomenclature, and Drug Classification (2003)
therefore, topical tacrolimus should be used after stopping phototherapy to decrease the risk of recurrent lesions (Bleuel and Eberlein, 2018)

10.1371/journal.pcbi.0030055 PLoS Comput
