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Red blood cells are highly affected by the loss of PKR because they lack mitochondria and are therefore reliant upon glycolysis for ATP generation

4 Pharmacological activities 4.1 Antidiabetic effect When left unchecked, high blood sugar levels can cause a cascade of oxidative stress, leading to severe and debilitating complications associated with diabetes

BOLD, Blood oxygenation level-dependent

Besides the optimal level of medium components (supplementary data), pH and temperature play an important role both in terms of enzyme production and its catalytic activity

It is thus not surprising that multiple layers of regulation are in place to fine-tune CYP19A1 activity