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Administrated resveratrol positively affects the synthesis of sirtuins, SIRT1 (a family of proteins NAD + -dependent histone deacetylases playing an important role in the regulation of metabolic pathways, see below) activating then superoxide dismutase 2 (Mn-SOD) expression in cardiomyocytes and improved cardiac functions (Tanno et al

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PMID: 69 CoplandAMackieGMScarfeLJinksELeckyDAJGudgeonNet al

The inhibition of p53 can downregulate the expression of LC3-II and perilipins needed for lipophagy, and thus, p53 plays a unique role as a tumor suppressor in lipophagy

Three pivotal features of ferroptosis in research foci So far, it has been demonstrated that subcellular cells undergoing ferroptosis may evolve at least three different pivotal features