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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Experimentally induced focal fibrosis, tubular atrophy, and cystic dilatation of distal tubules were obtained by exposing animals to toxic doses (Ottosen et al., 1984

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Additionally, according to White et al., the act of surgery initiates a series of events that include the release of inflammatory mediators, causing a temporary constriction of arterioles followed by vasodilation, increased blood flow, an increase in the permeability of post-capillary venules, and fluid leakage into the surrounding tissue [14]