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Availability of data and materials The datasets used and/or analyzed during the current study are available as MS Excel files (.xlsx) and RevMan file (.rm5) from the corresponding author upon reasonable request

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Upon activation of the immune system, inflammatory mediators such as cytokines (e.g., tumor necrosis factor, interleukin-6) and chemokines (Chen et al., 2017

The 3 APOE alleles have protein isoforms that differ only at 2 amino acid positions (112 and 158)

This work was supported by the Henan Provincial Hospital of Traditional Chinese Medicine Doctoral Research Start-up Fund (2024BSJJ14) and the Joint Research Project of Henan Provincial Traditional Chinese Medicine (2025LHZX2013)