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Pharmacodynamic (PD) biomarkers are defined as the biological response to a drug treatment (Sawyers 2008) and either are treatment specific or may represent endogenous phenotype changes in a subject due to a drug treatment (Beger and Colatsky 2011)
Realistic Expectations and Timeline It is important to remember that skin cells take time to turn over
J Biol Chem (1999) 274:363217
Kim, D.-K
174,175 In a retrospective analysis of 8207 patients, a consistent increase in the risk of death was observed with an MP greater than 17 J/min
