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The toxicity of dopamine has been demonstrated in a variety of in vitro models, and previous experiments have demonstrated the selective toxicity of dopamine in vivo after exogenous dopamine injection into the striatum, resulting in the selective toxicity of dopamine receptor nerve terminals and the loss of dopaminergic neurons in the substantia nigra [202,203]
In a recent study [25], nuclear magnetic resonance analysis of blood plasma metabolomic profiles from ME/CFS patients with comorbidities revealed significant lipoprotein anomalies
It has been estimated that 75% of total body carnitine levels come from diet and only 25% from endogenous synthesis [25]
Moreover, it has been found that mitochondrial functions and integrity can be affected by many of the risk factors of ASD, including toxins, immune activation, medicines, and metabolic disturbances [17]
(5) treated with CdCl 2 + Selenium
