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Rather, age-related premutational lesions may have occurred in these cells that are converted to the authentic mutation (most commonly a glycine to arginine substitution at codon 1,138) following fertilization, as a consequence of aberrant DNA repair in the zygote [5, 6]

Injectable protocols provide systemic exposure that may benefit skin through internal mechanisms

However, LT4 has a narrow therapeutic window, and around 30% of patients fail to stably achieve the recommended serum level of thyroid-stimulating hormone (TSH

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial