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A study published in Mechanisms of Ageing and Development reported that Deltaran, a DSIP-based compound, decreased tumor occurrence in mice by over twofold compared to control groups

However, current clinically approved agents, such as Ivosidenib [152,153,154], function by reversing the mutated IDH1 phenotype, thereby attenuating the tumors acquired sensitivity to PARP inhibition

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10.1002/mds.23732 Mov

One of the critical factors underlying these complications is oxidative stress, which is primarily driven by free radicals such as ROS and RNS